That would indicate game is working fine. If it doesn't means that game has problems as game should run without saves as well and give a New Game option on the main screen like rest of the games.
Fallout 3 as well as New Vegas have never crashed on my system.
How many mods do you have ?
okay so i was using fose and fomm, right?
i was already running fallout3.exe in compatibility mode, win xp sp3, as per suggestions. further, today i went in and decided to run fose.exe on the same compatibility mode.
BAM!!
no crashes. played a couple of hours with plenty of fast travel, loading, autosaving. but no crashes.
still using fellout+brighter nights+autosave mod.
[MENTION=73844]gameranand[/MENTION] : if it crashes anymore, i will try out your fix.