ME:R didn't run on Proton for me. So I had refunded it. Looks like it's supported now, so might re-buy next sale.All my gaming has been on Linux for 2+ years now. So, in this case, Proton.
How does one do modding in Proton ?
Modding depends on the kind of mod. If it's a setup exe file, you can use Proton Launcher to run it and choose the game from the list of installed games that comes up to run it in the same protonfix as the game. If it uses something like Mod Organizer, you could either use Lutris or look up SteamTinkerLaunch.