Yes, Delete the Autorun.inf file. But you may not be able to delete it. Because More likely than not this is a virus infection.
And AFAIK turn off all unrecognizable and unwanted programs from startup.
xplorer2 is a nice and free tool to browse such infected drives. If you double click the drive; the virus gets active each time.
I hope it isnt a virus but if it is, do ask here. Id be glad to help.