Usually people prefer to work with the highest Mx (possible) since boards hit the FSB wall quite fast. For LGA775 the norm was to find a balance between the NB and Mx, since the NB was separate and caused bottle necks. The best way for you to check, is to do it your self, and see which is more efficient. Run 2 MaxPii tests at the same speed but vary the Mx and FSB. Do one test at 14x * 236 and do another test at 12x * 275. Depends when you hit the FSB wall. Do remember via high FSB you heat the NB quicker and load it more. You would need to tweak the MCH voltage for this. Just do not keep increasing the vCore, which though easy, is bad OC methodology.