FF + Addons (PhishTank, NoScript, AdBlockPlus, JSView, WOT) +
A good Internet Security Solution:-
Paid: KIS2009 (2010 is also out I've heard)+Adware
Free: Avira Free version (antivirus only)/AVG8 + Komodo + Adware +Malwarebytes Malware remover
These would be pretty much resource hog...so, if u don't have enough (at least 2GB) RAM, don't install all.