look you must be having a file named setup.exe in both the drives delete them
and then go to folder options and view hidden files and folders
after that delete setup.ini
in both the drives
ONE IMP> DO NOT DELETE AND SETUPS INSIDE THE FOLDERS JUST ON OPENING THE DRIVES THERE..
its a virus called autoplay generator..
NORTON OR ANY AV CANT REMOVE IT
so just clean your temp folder and clean your registry by a good registry cleaner... also