What type of bootable medium you plan to create? BIOS MBR (Legacy Boot) or UEFI Boot?
If UEFI Boot and the ISO is UEFI bootable (which should be the case with newer Linux or Acronis etc) then it’s lot easier.
Using built-in GUI tool called ‘Disks’ create GPT partition scheme and create a FAT partition on the pen drive. Mount the ISO (Right click for options, ‘Open with Achieve Mounter’ in Ubuntu) and copy all of its contents from the Mounted ISO to the FAT partition. That’s it.
UEFI Specs make it a lot easier to boot off USB drives. The firmware (64 Bit) looks for \EFI\Boot\Bootx64.efi file when pointed to pen drive and starts loading it by default. As long as it’s designed as a valid bootloader, booting will proceed.
This method of copying or using Image Writer tools will work for most UEFI bootable ISOs where no single file inside is > 4 GB. However, for newer Windows 10 Releases this method will not work as single file install.wim is > 4 GB. Creating a single NTFS partition may or may not work as not all UEFI firmware’s support NTFS booting.
In that case you have to either split the file or use NTFS UEFI Driver. If interested, I can share the steps, however it needs to be carefully done, it’s not a single command operation.