absolutely safe.
Or if u r that afraid & u r a fresher to computing... just restart the comp... take out the drive then
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that's because ur drive is a 2gb one.. maybe with lotsa stuff's in it.. and ur OS is tryin to read/identify/index ur contents... silently.
Just b sure, u r still not transferring data when u r unpluggin/removing ur drive out.
Of course, u can always pull the usb out whenever u r not transferring data... & there r simpler methods to solve ur prob (like restart explorer only)... but this is a tension-proof one to a newcomer like u...